MIF In Colitis

The term colitis refers to several diseases, including Crohn disease and ulcerative colitis, that are characterized by recurrent or chronic inflammation of the bowl wall. This pathology results in severe and potentially life-threatening bowel dysfunction, including pain, bleeding, and diarrhoea. MIF has been shown to be overexpressed in human colitis patients, including in bowel tissue, and MIF-deficient mice exhibit dramatic reductions in disease severity. Moreover, anti-MIF antibody treatment is effective in preventing clinical disease in a mouse model of colitis, and MIF-overexpressing transgenic mice exhibit heightened sensitivity to bowel disease.